Perinatal maternal mental health and amygdala morphology in young adulthood

Varování

Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.
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GUMA Elisa ANDRÝSKOVÁ Lenka BRÁZDIL Milan CHAKRAVARTY M. Mallar MAREČKOVÁ Klára

Rok publikování 2023
Druh Článek v odborném periodiku
Časopis / Zdroj Progress in Neuro-Psychopharmacology and Biological Psychiatry
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www https://doi.org/10.1016/j.pnpbp.2022.110676
Doi http://dx.doi.org/10.1016/j.pnpbp.2022.110676
Klíčová slova Maternal anxiety; Perinatal depression; Amygdala; Volume; Surface area
Popis The pre- and perinatal environment is thought to play a critical role in shaping brain development. Specifically, maternal mental health and maternal care have been shown to influence offspring brain development in regions implicated in emotional regulation such as the amygdala. In this study, we used data from a neuroimaging follow-up of a prenatal birth-cohort, the European Longitudinal Study of Pregnancy and Childhood, to investigate the impact of early postnatal maternal anxiety/co-dependence, and prenatal and early-postnatal depression and dysregulated mood on amygdala volume and morphology in young adulthood (n = 103). We observed that in typically developing young adults, greater maternal anxiety/co-dependence after birth was significantly associated with lower volume (right: t = -2.913, p = 0.0045, ß = -0.523; left: t = -1.471, p = 0.144, ß = -0.248) and non-significantly associated with surface area (right: t = -3.502, q = 0.069, <10%FDR, ß = -0.090, left: t = -3.137, q = 0.117, <10%FDR, = -0.088) of the amygdala in young adulthood. Conversely, prenatal maternal depression and mood dysregulation in the early postnatal period was not associated with any volumetric or morphological changes in the amygdala in young adulthood. Our findings provide evidence for subtle but long-lasting alterations to amygdala morphology associated with differences in maternal anxiety/co-dependence in early development.
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