The exposure of Czech firefighters to perfluoroalkyl substances and polycyclic aromatic hydrocarbons: CELSPAC – FIREexpo case-control human biomonitoring study

Logo poskytovatele
Logo poskytovatele
Logo poskytovatele
Logo poskytovatele
Logo poskytovatele

Varování

Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.
Autoři

ŘIHÁČKOVÁ Katarína PINDUR Aleš KOMPRDOVÁ Klára PÁLEŠOVÁ Nina KOHOUTEK Jiří ŠENK Petr NAVRÁTILOVÁ Jana ANDRÝSKOVÁ Lenka ŠEBEJOVÁ Ludmila HŮLEK Richard ISMAEL Mazen ČUPR Pavel

Rok publikování 2023
Druh Článek v odborném periodiku
Časopis / Zdroj SCIENCE OF THE TOTAL ENVIRONMENT
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://www.sciencedirect.com/science/article/pii/S0048969723019174?dgcid=rss_sd_all
Doi http://dx.doi.org/10.1016/j.scitotenv.2023.163298
Klíčová slova Firefighters; Human biomonitoring; Perfluoroalkyl substances; Polycyclic aromatic hydrocarbons; Cohort profile; HBM value
Přiložené soubory
Popis The CELSPAC – FIREexpo biomonitoring study investigates the long-term effects of chemical exposure on firefighters' wellness and fitness. It aims to provide science-based measures to minimize the health risks of the firefighting occupation. Here, we present the study design, cohort profile, and first results with respect to internal per- and polyfluoroalkyl substances (PFAS) and polycyclic aromatic hydrocarbons (PAH) levels in study participants. Participants (n = 166) were divided into three subcohorts: i) newly recruited firefighters, ii) professional firefighters with several years' experience, and iii) the control group. Participants underwent physical performance tests, provided information on their lifestyle and diet, and urine and blood samples 1–4 times within an 11-week period. 12 serum PFAS and 10 urinary hydroxylated PAH (OH-PAH) levels were determined using HPLC-MS/MS and compared between subcohorts and samplings. The association of internal exposure with reported lifestyles and occupational factors was investigated using Spearman's correlation, principal component analysis, and multivariate regression analysis. ?PFAS levels in firefighters were significantly higher than in the control group and were mostly associated with the length of firefighting career, age, blood donation, and population size. 10.9 % and 7.6 % of measurements exceeded the HBM-I or HBM-II value for PFOS and PFOA, respectively. Urinary ?PAH levels increased significantly after training with burning wooden pallets, but none of them exceeded the no observed genotoxic effect level. Firefighters’ occupational exposure, its sources, and pathways, need to be systematically monitored and investigated on a long-term and individual basis. The CELSPAC – FIREexpo study helps to clarify the degree of occupational exposure to the given compounds and the subsequent risks to firefighters.
Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.