Enhancing cisplatin anticancer effectivity and migrastatic potential by modulation of molecular weight of oxidized dextran carrier

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Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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MUNSTER L. FOJTŮ Michaela MUCHOVA M. LATECKA F. KACEROVA S. CAPAKOVA Z. JURIŇÁKOVÁ Tamara KURITKA I. MASAŘÍK Michal VICHA J.

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj Carbohydrate Polymers
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://reader.elsevier.com/reader/sd/pii/S0144861721008481?token=6B980116FFE89BE9644D630E5871F9E438C2A85EC19DD545C3ABE52B8108EA349F2BD805D3531CE612288A0775CE71A2&originRegion=eu-west-1&originCreation=20220124064804
Doi http://dx.doi.org/10.1016/j.carbpol.2021.118461
Klíčová slova Drug-delivery; Dextran; Periodate oxidation; Molecular weight; Cisplatin; Carrier
Popis The molecular weight (M-w) of dextran derivatives, such as regioselectively oxidized dicarboxydextran (DXA), is greatly influencing their faith in an organism, which could be possibly used to improve anticancer drug delivery. Here we present a modified method of sulfonation-induced chain scission allowing direct and accurate control over the M-w of DXA without increasing its polydispersity. Prepared DXA derivatives (M-w = 10-185 kDa) have been conjugated to cisplatin and the M-w of the carrier found to have a significant impact on cisplatin release rates, in vitro cytotoxicity, and migrastatic potential. Conjugates with the high-M-w DXA showed particularly increased anticancer efficacy. The best conjugate was four times more effective against malignant prostatic cell lines than free cisplatin and significantly inhibited the ovarian cancer cell migration. This was traced to the characteristics of spontaneously formed cisplatin-crosslinked DXA nanogels influenced by M-w of DXA and amount of loaded cisplatin.
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