Platelet-derived chemokines, PF-4 and RANTES, are significantly increased in hemodynamically significant degenerative aortic stenosis

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Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.
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MOTOVSKA Z. ODVODYOVA D. KARPISEK M. HRABAKOVA H. KOCKA V. SIMKOVA I. KATINA Stanislav WIDIMSKY P.

Rok publikování 2011
Druh Článek v odborném periodiku
Časopis / Zdroj International Journal of Cardiology
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www http://www.sciencedirect.com/science/article/pii/S0167527311008618
Doi http://dx.doi.org/10.1016/j.ijcard.2011.08.021
Obor Aplikovaná statistika, operační výzkum
Klíčová slova Degenerative aortic stenosis; Platelet-derived chemokines; Platelet factor-4 (CXCL4); RANTES (CCL5)
Popis Aortic valve stenosis (AoS) is the most common acquired valvular disorder found in developed countries, being present in 2% to 7% of adults over the age of 65 [1], [2] and [3]. Calcified AoS is a chronic progressive disease. The pathomechanisms leading to valve degeneration remain unknown. Valve disease shares many features with atherosclerosis. Platelet activation is an important constituent of the atherosclerotic process [4] and [5]. The study focused on two platelet-derived chemokines, which bridge three important components of atherogenesis: platelet activation, inflammation, and generation of atheroma. The study group was comprised of 124 consecutive patients being considered for aortic valve replacement for symptomatic degenerative trileaflet valvular AoS, and were undergoing cardiac catheterization in the Cardiocentre [6]. The exclusion criterion was the presence of an additional hemodynamically significant valve disease.
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