Structural conservation of antibiotic interaction with ribosomes

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Authors

PATERNOGA Helge CROWE-MCAULIFFE Caillan BOCK Lars V KOLLER Timm O MORICI Martino BECKERT Bertrand MYASNIKOV Alexander G GRUBMUELLER Helmut NOVÁČEK Jiří WILSON Daniel N

Year of publication 2023
Type Article in Periodical
Magazine / Source NATURE STRUCTURAL & MOLECULAR BIOLOGY
MU Faculty or unit

Central European Institute of Technology

Citation
Web https://www.nature.com/articles/s41594-023-01047-y
Doi http://dx.doi.org/10.1038/s41594-023-01047-y
Keywords ribosome; antibiotics; CryoEM; antibiotic–ribosome interactions; RNA-targeting therapies
Description Here the authors present the high-resolution structures of 17 antibiotics bound to Escherichia coli ribosomes, which may inform the development of new antibacterial agents. Their results unveil a conserved manner of antibiotic binding to the ribosome, including ordered water molecules.
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