The effect of deep brain stimulation in Parkinson's disease reflected in EEG microstates

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This publication doesn't include Faculty of Economics and Administration. It includes Central European Institute of Technology. Official publication website can be found on muni.cz.
Authors

LAMOŠ Martin BOČKOVÁ Martina GOLDEMUNDOVÁ Sabina BALÁŽ Marek CHRASTINA Jan REKTOR Ivan

Year of publication 2023
Type Article in Periodical
Magazine / Source NPJ PARKINSONS DISEASE
MU Faculty or unit

Central European Institute of Technology

Citation
Web https://www.nature.com/articles/s41531-023-00508-x
Doi http://dx.doi.org/10.1038/s41531-023-00508-x
Keywords deep brain stimulation; high-density EEG; Parkinson's disease; EEG microstates
Description Mechanisms of deep brain stimulation (DBS) on cortical networks were explored mainly by fMRI. Advanced analysis of high-density EEG is a source of additional information and may provide clinically useful biomarkers. The presented study evaluates EEG microstates in Parkinson's disease and the effect of DBS of the subthalamic nucleus (STN). The association between revealed spatiotemporal dynamics of brain networks and changes in oscillatory activity and clinical examination were assessed. Thirty-seven patients with Parkinson's disease treated by STN-DBS underwent two sessions (OFF and ON stimulation conditions) of resting-state EEG. EEG microstates were analyzed in patient recordings and in a matched healthy control dataset. Microstate parameters were then compared across groups and were correlated with clinical and neuropsychological scores. Of the five revealed microstates, two differed between Parkinson's disease patients and healthy controls. Another microstate differed between ON and OFF stimulation conditions in the patient group and restored parameters in the ON stimulation state toward to healthy values. The mean beta power of that microstate was the highest in patients during the OFF stimulation condition and the lowest in healthy controls; sources were localized mainly in the supplementary motor area. Changes in microstate parameters correlated with UPDRS and neuropsychological scores. Disease specific alterations in the spatiotemporal dynamics of large-scale brain networks can be described by EEG microstates. The approach can reveal changes reflecting the effect of DBS on PD motor symptoms as well as changes probably related to non-motor symptoms not influenced by DBS.
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