Evolution of RNA viruses in trypanosomatids: new insights from the analysis of Sauroleishmania

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Authors	KLOCEK Donnamae GRYBCHUK Danyil TICHA Lucie VOTYPKA Jan VOLF Petr KOSTYGOV Alexei Yu YURCHENKO Vyacheslav
Year of publication	2023
Type	Article in Periodical
Magazine / Source	Parasitology research
MU Faculty or unit	Central European Institute of Technology
Citation
Web	https://link.springer.com/article/10.1007/s00436-023-07928-x
Doi	http://dx.doi.org/10.1007/s00436-023-07928-x
Keywords	Leishmania (Sauroleishmania) adleri; L; (S; ) gymnodactyli; ) hoogstraali; ) tarentolae; Narnaviridae; LRV2
Attached files	s00436-023-07928-x.pdf
Description	RNA viruses play an important role in Leishmania biology and virulence. Their presence was documented in three (out of four) Leishmania subgenera. Sauroleishmania of reptiles remained the only underinvestigated group. In this work, we analyzed the viral occurrence in Sauroleishmania spp. and detected RNA viruses in three out of seven isolates under study. These viruses were of two families-Narnaviridae and Totiviridae. Phylogenetic inferences demonstrated that totiviruses from L. adleri and L. tarentolae group together within a larger cluster of LRV2s, while a narnavirus of L. gymnodactyli appeared as a phylogenetic relative of narnaviruses of Blechomonas spp. Taken together, our work not only expanded the range of trypanosomatids that can host RNA viruses but also shed new light on the evolution and potential routes of viral transmission in these flagellates.
Related projects:	National Institute of Virology and Bacteriology