Meiotic exit in Arabidopsis is driven by P-body-mediated inhibition of translation

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Authors

CAIRO CALZADA Albert VARGOVÁ Anna SHUKLA Neha CAPITAO Claudio MIKULKOVÁ Pavlína VALUCHOVÁ Soňa PEČINKOVÁ Jana BULANKOVA Petra ŘÍHA Karel

Year of publication 2022
Type Article in Periodical
Magazine / Source Science
MU Faculty or unit

Central European Institute of Technology

Citation
Web https://www.science.org/doi/10.1126/science.abo0904
Doi http://dx.doi.org/10.1126/science.abo0904
Keywords MESSENGER-RNA DECAY; SMG7; PROGRAM; PROTEIN; MEIOSIS; REVEALS;BODIES
Description Meiosis, at the transition between diploid and haploid life cycle phases, is accompanied by reprograming of cell division machinery and followed by a transition back to mitosis. We show that, in Arabidopsis, this transition is driven by inhibition of translation, achieved by a mechanism that involves processing bodies (P-bodies). During the second meiotic division, the meiosis-specific protein THREE-DIVISION MUTANT 1 (TDM1) is incorporated into P-bodies through interaction with SUPPRESSOR WITH MORPHOGENETIC EFFECTS ON GENITALIA 7 (SMG7). TDM1 attracts eIF4F, the main translation initiation complex, temporarily sequestering it in P-bodies and inhibiting translation. The failure of tdm1 mutants to terminate meiosis can be overcome by chemical inhibition of translation. We propose that TDM1-containing P-bodies down-regulate expression of meiotic transcripts to facilitate transition of cell fates to postmeiotic gametophyte differentiation.
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