OverProt: secondary structure consensus for protein families

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Authors

MIDLIK Adam HUTAŘOVÁ VAŘEKOVÁ Ivana HUTAŘ Jan CHARESHNEU Aliaksei BERKA Karel SVOBODOVÁ Radka

Year of publication 2022
Type Article in Periodical
Magazine / Source Bioinformatics
MU Faculty or unit

Faculty of Science

Citation
Web https://academic.oup.com/bioinformatics/article/38/14/3648/6604272
Doi http://dx.doi.org/10.1093/bioinformatics/btac384
Keywords protein family; OverProt
Description Every protein family has a set of characteristic secondary structures. However, due to individual variations, a single structure is not enough to represent the whole family. OverProt can create a secondary structure consensus, showing the general fold of the family as well as its variation. Our server provides precomputed results for all CATH superfamilies and user-defined computations, visualized by an interactive viewer, which shows the secondary structure element type, length, frequency of occurrence, spatial variability and beta-connectivity.
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