Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case-control study

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Authors

BARTÁKOVÁ Julie DEISSOVÁ Tereza SLEZÁKOVÁ Simona BARTOVA Jirina PETANOVA Jitka KUKLÍNEK Pavel FASSMANN Antonín BOŘILOVÁ LINHARTOVÁ Petra DUŠEK Ladislav IZAKOVIČOVÁ HOLLÁ Lydie

Year of publication 2022
Type Article in Periodical
Magazine / Source BMC Oral Health
MU Faculty or unit

Faculty of Medicine

Citation
Web https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-022-02115-3
Doi http://dx.doi.org/10.1186/s12903-022-02115-3
Keywords Recurrent aphthous stomatitis; Angiotensin I converting enzyme; Polymorphism; Haplotype; Sex difference
Description Background Recurrent aphthous stomatitis (RAS) is multifactorial disease with unclear etiopathogenesis. The aim of this study was to determine distribution of the angiotensin I converting enzyme (ACE) gene polymorphisms and their influence on RAS susceptibility in Czech population. Methods The study included 230 subjects (143 healthy controls and 87 patients with RAS) with anamnestic, clinical and laboratory data. Five ACE gene polymorphisms (rs4291/rs4305/rs4311/rs4331/rs1799752 = ACE I/D) were determined by TaqMan technique. Results The allele and genotype distributions of the studied ACE I/D polymorphisms were not significantly different between subjects with/without RAS (P-corr > 0.05). However, carriers of II genotype were less frequent in the RAS group (OR = 0.48, 95% CI = 0.21-1.12, P = 0.059). Stratified analysis by sex demonstrated lower frequency of II genotype in women (OR = 0.33, 95% CI = 0.09-1.17, P < 0.035, P-corr > 0.05, respectively) than in men with RAS (P > 0.05). Moreover, the frequency of AGTGD haplotype was significantly increased in RAS patients (OR = 13.74, 95% CI = 1.70-110.79, P = 0.0012, P-corr < 0.05). In subanalysis, TGD haplotype was significantly more frequent in RAS patients (P < 0.00001) and CGI haplotype was less frequent in RAS patients (P < 0.01), especially in women (P = 0.016, P-corr > 0.05). Conclusions Our study indicates that while the AGTGD and TGD haplotypes are associated with increased risk of RAS development, CGI haplotype might be one of protective factors against RAS susceptibility in Czech population.
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