Generation of three human iPSC lines from patients with a spontaneous late-onset Alzheimer's disease and three sex- and age-matched healthy controls

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Authors

RAŠKA Jan KLÍMOVÁ Hana SHEARDOVÁ Kateřina FEDOROVÁ Veronika HŘÍBKOVÁ Hana POSPÍŠILOVÁ Veronika VOCHYÁNOVÁ Simona VÁŇOVÁ Tereza BOHAČIAKOVÁ Dáša

Year of publication 2021
Type Article in Periodical
Magazine / Source Stem cell research
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.sciencedirect.com/science/article/pii/S1873506121002245?via%3Dihub
Doi http://dx.doi.org/10.1016/j.scr.2021.102378
Keywords human iPSC lines; spontaneous late-onset Alzheimer’s disease
Description Human induced pluripotent stem cell (iPSC) lines were generated from patients with spontaneous late-onset Alzheimer's disease (AD) and three healthy control individuals. Peripheral blood mononuclear cells were reprogrammed with Yamanaka factors (OSKM) using a commercially available Epi5 Reprogramming Kit. The pluripotency of iPSCs was confirmed by the expression of pluripotency factors and by their ability to differentiate to all three germ layers in vitro. Newly derived cell lines can be used to model Alzheimer's disease in vitro.
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