AC Pulsed Field Ablation Is Feasible and Safe in Atrial and Ventricular Settings: A Proof-of-Concept Chronic Animal Study

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Authors

CALUORI Guido ODEHNALOVÁ Eva JADCZYK Tomasz PEŠL Martin PAVLOVÁ Iveta VALÍKOVÁ Lucia HOLZINGER Steffen NOVOTNÁ Veronika ROTREKL Vladimír HAMPL Aleš CRHA Michal ČERVINKA Dalibor STÁREK Zdeněk

Year of publication 2020
Type Article in Periodical
Magazine / Source Frontiers in bioengineering and biotechnology
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.frontiersin.org/articles/10.3389/fbioe.2020.552357/full
Doi http://dx.doi.org/10.3389/fbioe.2020.552357
Keywords pulsed field ablation; irreversible electroporation (IRE); radiofrequency ablation; atrial fibrillation; ventricular arrhythmia (VA); preclinical cardiology
Description Pulsed field ablation (PFA) exploits the delivery of short high-voltage shocks to induce cells death via irreversible electroporation. The therapy offers a potential paradigm shift for catheter ablation of cardiac arrhythmia. We designed an AC-burst generator and therapeutic strategy, based on the existing knowledge between efficacy and safety among different pulses. We performed a proof-of-concept chronic animal trial to test the feasibility and safety of our method and technology.
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