Extramedullary disease in multiple myeloma - controversies and future directions

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Authors

ŠEVČÍKOVÁ Sabina MINARIK Jiri STORK Martin JELINEK Tomas POUR Ludek HAJEK Roman

Year of publication 2019
Type Article in Periodical
Magazine / Source BLOOD REVIEWS
MU Faculty or unit

Faculty of Medicine

Citation
Web http://dx.doi.org/10.1016/j.blre.2019.04.002
Doi http://dx.doi.org/10.1016/j.blre.2019.04.002
Keywords Multiple myeloma; Extramedullary disease; Treatment; Resistance; Biomarker
Description Extramedullary disease of multiple myeloma (EM) remains a treatment challenge even in the era of new drugs. While many reports analyzing various aspects of EM have been published, mechanism of EM development has not been clarified yet. This review summarizes current knowledge about this clinical entity, including its history, diagnostics, imaging methods, incidence, prognosis, current treatment options, risk factors and known molecular mechanisms that might be involved in pathogenesis of EM.
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