Sequence-dependent separation of trinucleotides by ion-interaction reversed-phase liquid chromatography A structure-retention study assisted by soft-modelling and molecular dynamics

Warning

This publication doesn't include Faculty of Economics and Administration. It includes Central European Institute of Technology. Official publication website can be found on muni.cz.

Authors

MIKULÁŠEK Kamil JAROŇ Kamil KULHÁNEK Petr BITTOVÁ Miroslava HAVLIŠ Jan

Year of publication 2016
Type Article in Periodical
Magazine / Source Journal of Chromatography A
MU Faculty or unit

Central European Institute of Technology

Citation
Web supplementary data
Doi http://dx.doi.org/10.1016/j.chroma.2016.09.060
Field Analytic chemistry
Keywords Sequence-dependent separation; Ion-interaction reversed-phase liquid chromatography; Trinucleotides; Oligonucleotide sequence isomers; QSRR; Molecular dynamics
Attached files
Description Ultrashort oligonucleotides show consistent sequence-dependent separation behaviour, described via soft-modelling and molecular dynamics. Important factors determining this phenomenon were identified to be solvent accessible surface areas and electrostatic work of molecule transfer from vacuum into solvent, representing physico-chemical properties of the studied molecules.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.