Project information
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2018127
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
- Central European Institute of Technology
- Cooperating Organization
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Institute of Biotechnology CAS
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 322
2023
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Synthesis of Enantiomerically Pure Bambus[6]urils Utilizing Orthogonal Protection of Glycolurils
Journal of Organic Chemistry, year: 2023, volume: 88, edition: 16, DOI
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Tailoring hydroxyapatite morphology via the effect of divalent cations on the hydrolysis of α-TCP: Oriented crystal growth towards the application in water treatment
Ceramics International, year: 2023, volume: 49, edition: 20, DOI
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Targeting undruggable oncoproteins c-Myc and N-Myc by the 9aaTADs
Year: 2023, type: Appeared in Conference without Proceedings
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The NFkB activation domain is 14-amino-acid-long variant of the 9aaTAD
The Biochemical journal, year: 2023, volume: 480, edition: 5, DOI
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Tick-borne encephalitis: A comprehensive review of the epidemiology, virology, and clinical picture
Reviews in Medical Virology, year: 2023, volume: 33, edition: 5, DOI
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Unveiling the nanotoxicological aspects of Se nanomaterials differing in size and morphology
BIOACTIVE MATERIALS, year: 2023, volume: 20, edition: FEB, DOI
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Vaccination against tick-borne encephalitis elicits a detectable NS1 IgG antibody response
Journal of Virological Methods, year: 2023, volume: 322, edition: December, DOI
2022
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14-3-3 protein isoforms: mutual dimerization propensities screening kit
Year: 2022, type: Conference abstract
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35th NMR Valtice
Year: 2022, type: Conference
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A GP1BA Variant in a Czech Family with Monoallelic Bernard-Soulier Syndrome
International Journal of Molecular Sciences, year: 2022, volume: 23, edition: 2, DOI