Influence of circadian clocks on optimal regime of central C-N metabolism of cyanobacteria

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Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Fakultu informatiky. Oficiální stránka publikace je na webu muni.cz.
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ČERVENÝ Jan ŠALAGOVIČ Jakub MUZIKA František ŠAFRÁNEK David SCHREIBER Igor

Rok publikování 2018
Druh Kapitola v knize
Fakulta / Pracoviště MU

Fakulta informatiky

Citace
Popis Mechanistic aspects of cyanobacteria clock and metabolism have been analyzed in considerable detail during recent decades, but only limited knowledge is available about particular link(s) between the clock and controlled metabolic processes. We describe a case study where we couple a mechanistic model of a circadian oscillator with a model of central carbon-nitrogen metabolism and apply formal methods based on temporal logic and bifurcation analysis to examine response of the metabolic part of the combined model to the autonomous clock oscillations. The analysis identified a set of parametric groups that, when applied to the in silico system, lead either to an optimal configuration of metabolic pathways for most efficient rhythmic function of the metabolism or to (oscillatory) system death. Under controlled conditions in monitored environments, such as cultivation in photobioreactors, the knowledge can be used for optimal regulation of production capacity that would reflect dynamic constraints of real world systems.
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