Diffusion kurtosis imaging detects the time-dependent progress of pathological changes in the oral rotenone mouse model of Parkinson's disease

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Authors	KHAIRNAR Amit Suresh RUDÁ Jana ARAB Anas HADJISTYLLIS Constantinos ŠEJNOHA MINSTEROVÁ Alžběta SHANG Qi CHOVSEPAIN Alexandra DRAŽANOVÁ Eva SZABÓ Nikoletta STARČUK Zenon REKTOROVÁ Irena PAN-MONTOJO Francisco
Year of publication	2021
Type	Article in Periodical
Magazine / Source	Journal of Neurochemistry
MU Faculty or unit	Central European Institute of Technology
Citation
Web	https://onlinelibrary.wiley.com/doi/10.1111/jnc.15449
Doi	http://dx.doi.org/10.1111/jnc.15449
Keywords	alpha synuclein; diffusion kurtosis imaging; MRI; Parkinsons disease; rotenone; tract-based spatial statistics
Description	We test the utility and sensitivity of the diffusion kurtosis imaging (DKI) in detecting progressive microstructural changes in several brain regions of mice exposed to chronic intragastric administration of rotenone,a mouse model that mimics the spatiotemporal progression of PD-like pathology from the ENS to the SN as described by Braak's staging.
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