Project information
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2018127
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
- Central European Institute of Technology
- Cooperating Organization
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Institute of Biotechnology CAS
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 322
2021
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Business Research Forum
Year: 2021, type: Popularization text
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Capsid opening enables genome release of iflaviruses.
Science advances, year: 2021, volume: 7, edition: 1, DOI
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Capsid Structure of Leishmania RNA Virus 1
Journal of Virology, year: 2021, volume: 95, edition: 3, DOI
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Cargo Release from Nonenveloped Viruses and Virus-like Nanoparticles: Capsid Rupture or Pore Formation
ACS Nano, year: 2021, volume: 15, edition: 12, DOI
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Cell based AFM biosensensing for screening of pulmonary-drug related arrhytmic effects
Nanocon 2020, year: 2021
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Cellular mechanosensing by means of atomic force microscopy
Year: 2021, type: Conference abstract
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CF Day
Year: 2021, type: Conference
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c-kit2 G-quadruplex stabilized via a covalent probe: exploring G-quartet asymmetry
Nucleic Acids Research, year: 2021, volume: 49, edition: 15, DOI
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c-kit2 G-Quadruplex Stabilized via a Covalent Probe: Exploring G-Quartet Asymmetry
Year: 2021, type: Conference abstract
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Classification of a Violacein-Producing Psychrophilic Group of Isolates Associated with Freshwater in Antarctica and Description of Rugamonas violacea sp. nov.
Microbiology Spectrum, year: 2021, volume: 9, edition: 1, DOI